Besides, a higher ESR might occur in r enal failure, obesity, ageing, and female sex. CRP C-reactive protein is the other test for the detection of inflammation. It is more accurate, sensitive and quick.
Also, CRP is a better marker for the detection of the acute phase of inflammation. S erum amyloid A protein and procalcitonin are the other two markers of acute phase inflammation. Sometimes, a fold increase can be observed in both acute and chronic phases of inflammation.
Figure 2: C-Reactive Protein. Moreover, in response to both acute and chronic inflammation, cytokines, mainly interleukin-6, is released into the bloodstream. As a consequent response, the liver releases CRP. In the innate immune response, it acts as an acute-phase reactant by attaching to microorganisms and damaged cellular components via phosphocholine. So, this activates both the phagocytosis and complement system. Therefore, CRP responds to inflammation quickly.
However, the highest concentration of CRP occurs in less than two days of inflammation and the concentration falls rapidly with the resolving of the inflammation. ESR erythrocyte sedimentation rate refers to the rate at which red blood cells in anticoagulated whole blood descend in a standardized tube over a period of one-hour. CRP is the preferred first test to support a diagnosis of inflammatory or infectious conditions, rather than ESR.
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Endocrine System. Gastrointestinal System. Geriatric Medicine. Head and Neck. Mental Health. Palliative Care. Preventative Health. Email Alerts Don't miss a single issue. Sign up for the free AFP email table of contents. C-reactive protein is a more sensitive and specific reflection of the acute phase of inflammation than is the erythrocyte sedimentation rate. In the first 24 hours of a disease process, the C-reactive protein will be elevated, whereas the erythrocyte sedimentation rate may be normal.
If the source of inflammation is removed, the C-reactive protein will return to normal within a day or so, whereas the erythrocyte sedimentation rate will remain elevated for several days until excess fibrinogen is removed from the serum. Rheumatologic Hematologic.
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