Blood donation: You should not give blood during treatment with alitretinoin and for one month after stopping treatment in case the blood is given to a pregnant woman. Bones and joints: Alitretinoin may cause some minor bone changes. Talk to your doctor if you notice aches or pains in the bones or joints, or have difficulty moving. Your doctor may monitor you for bone changes while you are taking this medication. Cholesterol: Alitretinoin can cause increases in cholesterol and other lipids in the blood.
If you are already at an increased risk of developing high cholesterol, for example if you have a family history of high cholesterol, diabetes, are overweight, or have an increased alcohol intake, you are more likely to experience this.
If you are at any increased risk of developing increased blood lipids, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Depression and suicidal thoughts: Retinoid medications have been known to cause mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, or notice them in a family member who is taking this medication, contact your doctor as soon as possible. Diabetes: Alitretinoin may cause a loss of control of blood sugar levels for people with diabetes. If you have diabetes, or anyone in your family has diabetes, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
You may need to check your blood glucose levels more often. Stomach and bowels : Alitretinoin may cause inflammatory bowel disease IBD. If you have inflammatory bowel disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
If you experience severe abdominal pain, rectal bleeding, or severe diarrhea, you should stop using this medication and contact your doctor. Liver function: Retinoids like alitretinoin have been linked to inflammation of the liver in some cases.
If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.
If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor as soon as possible.
Neurologic effects: Alitretinoin has been linked to causing intracranial hypertension increased pressure around the brain , also known as pseudotumor cerebri. Early symptoms of this condition include headache, nausea, vomiting, and visual disturbances.
If you have these symptoms call your doctor immediately. Skin care: Alitretinoin causes irritated, dry skin and lips. Ask your doctor or pharmacist for appropriate moisturizers and lip balms to use to prevent severe dryness.
While you are taking alitretinoin, avoid exfoliators, waxing, and dermabrasion. Sun sensitivity: Alitretinoin may make you more likely to burn in the sun. Use appropriate measures to prevent excessive exposure to the sun. Wear a hat and sunglasses when out in the sun, use a sunscreen that provides an SPF of 30 or higher, and avoid going out in the sun between 10 am and 2 pm when the sun is at its strongest. Avoid using sun lamps and tanning beds. Thyroid disease: This medication may cause changes in thyroid function.
The thyroid gland produces hormones that help the body make energy and organs work properly. If you experience unexpected fatigue, intolerance to cold or weight gain, contact your doctor as soon as possible. If you have thyroid problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Your doctor may want to test your thyroid function regularly with blood tests while you are taking this medication. Vision: This medication may cause dry eyes. This usually disappears after stopping the medication. Using a lubricating eye drop may help with this side effect. It may take up to 2 months to notice improvement. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
To relieve dry eyes, you may use a lubricating eye ointment or tear replacement eye drops. Ask your pharmacist for details. If you wear contact lenses and get dry eyes, you may need to wear glasses while using this medication. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Stop taking alitretinoin and tell your doctor right away if any of these serious side effects occur:. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:. This is not a complete list of possible side effects.
If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at Before taking alitretinoin, tell your doctor or pharmacist if you are allergic to it; or to vitamin A-related drugs other retinoids such as isotretinoin ; or if you have any other allergies.
This product may contain inactive ingredients such as soy , which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of:. Do not donate blood while taking this drug and for at least 1 month after stopping treatment.
This will lessen the chance of your blood being given to a pregnant woman. This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.
Alitretinoin may cause vision changes, including decreased night vision. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication.
If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. Many of these side effects can be managed, and some may go away on their own over time. Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects. Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Stop taking the medication and seek immediate medical attention if any of the following occur:. Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication. Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health.
These factors may affect how you should use this medication. Blood donation: You should not give blood during treatment with alitretinoin and for one month after stopping treatment in case the blood is given to a pregnant woman. Bones and joints: Alitretinoin may cause some minor bone changes. Talk to your doctor if you notice aches or pains in the bones or joints, or have difficulty moving. Your doctor may monitor you for bone changes while you are taking this medication.
Cholesterol: Alitretinoin can cause increases in cholesterol and other lipids in the blood. If you are already at an increased risk of developing high cholesterol, for example if you have a family history of high cholesterol, diabetes, are overweight, or have an increased alcohol intake, you are more likely to experience this. If you are at any increased risk of developing increased blood lipids, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Depression and suicidal thoughts: Retinoid medications have been known to cause mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, or notice them in a family member who is taking this medication, contact your doctor as soon as possible.
Diabetes: Alitretinoin may cause a loss of control of blood sugar levels for people with diabetes. If you have diabetes, or anyone in your family has diabetes, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
You may need to check your blood glucose levels more often. Stomach and bowels : Alitretinoin may cause inflammatory bowel disease IBD. If you have inflammatory bowel disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
If you experience severe abdominal pain, rectal bleeding, or severe diarrhea, you should stop using this medication and contact your doctor. Liver function: Retinoids like alitretinoin have been linked to inflammation of the liver in some cases. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Your doctor may want to test your liver function regularly with blood tests while you are taking this medication. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor as soon as possible.
The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect. The side effects listed above may not include all of the side effects reported by the medicine's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
If you think you have experienced a side effect from a medicine or vaccine you should check the patient information leaflet. This lists the known side effects and what to do if you get them. You can also get advice from your doctor, nurse or pharmacist. If they think it's necessary they'll report it for you. You can also report side effects yourself using the yellow card website: www. It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine.
Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to make sure that the combination is safe. You should not take vitamin A supplements while you are taking this medicine, because this may result in a condition similar to vitamin A overdose. Bear in mind that vitamin A may be found in multivitamin supplements. Other retinoid medicines should not be taken in combination with this medicine for the same reason. Women using hormonal contraceptives to prevent pregnancy should not take the herbal remedy St Johns wort Hypericum perforatum while taking this medicine, because it can make hormonal contraceptives such as the pill less effective at preventing pregnancy.
Tetracycline-type antibiotics, eg minocycline, doxycycline, tetracycline , must not be used in combination with this medicine, because the combination may increase the risk of raised pressure within the skull benign intracranial hypertension. The antifungal medicine ketoconazole may prevent the breakdown of alitretinoin in the body.
If you are prescribed a course of ketoconazole your doctor may want to temporarily lower your dose of this medicine. There are currently no other medicines available in the UK that contain alitretinoin as the active ingredient. For background information about our medicine factsheets, including the references used to produce them, click here. Last updated Parenting Mental health Healthy eating Conditions Follow.
Type keyword s to search. What is Toctino used for? Severe long-term eczema affecting the hands. Toctino is licensed for use in adults whose hand eczema has not been controlled by potent corticosteroid creams, ointments or lotions. How does Toctino work? Important information about Toctino Toctino capsules should be taken with a meal. They should be swallowed whole and not chewed. It also increases the risk of miscarriage.
For this reason, your doctor will not prescribe the treatment to women who could get pregnant, unless the following criteria of the Pregnancy Prevention Programme are met: At least one, but preferably two, effective methods of contraception for example the pill and condoms must be used at all times to prevent pregnancy.
You will be given advice on what methods to use.
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